Methyl iodide → 62306-03-0
Reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH2:10].[CH3:11][I:12]>>[IH:12].[CH3:11][N:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1][C:2]1=[NH:10]Participants
3
Procedure
Benzothiazol-2-ylamine (1.0 g, 6.6 mmol) and methyl iodide (0.48 mL, 7.9 mmol) were processed as described in Example 46A to provide 1.2 g (60%) of the title compound. 1H NMR (DMSO-d6, 300 MHz) δ ppm 3.73 (s, 3H), 7.39-7.47 (m, 1H), 7.59 dt, J=7.8, 1.0 Hz, 1H), 7.65-7.71 (m, 1H), 7.99 (d, J=8.1 Hz, 1H), 9.99 (s, 2H); MS (DCI/NH3) m/z 165 (M+H)+.
Sources & evidence
- ORD record
- ord-3ee2f8f77bb443c2990c3d3e53ccc4e9
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09006275B2
Reaction notes
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