HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1470008Generated: October 26, 2026
1-Bromo-3,6-dioxaheptane → Ammonium Hydroxide
https://huagongshe.com/reaction/1470008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-3,6-dioxaheptane | HCID 123532 | — |
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-(2-(2-methoxyethoxy)ethyl)-5-methylthiazol-2(3H)-imine | HCID 66858728 | — |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (1.5 g, 13.0 mmol) and 1-bromo-2-(2-methoxyethoxy)ethane (2.0 mL, 14.5 mmol) was warmed to 85° C. and stirred for 5 hours. The mixture was cooled to ambient temperature and the residue was purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 217 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09006275B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-0cbd62efdda7433dabdc9f1b4b243697 |
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| Source note | uspto-grants-2015_04 |
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