Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → HCID 178495763, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 반응물 | N-(5-bromo-1,3-thiazol-2-yl)adamantane-1-carboxamide | HCID 49760640 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 생성물 | HCID 178495763 | HCID 178495763 | — |
반응 단계
A solution of Example 131A (2.55 g, 7.43 mmol), 1-bromo-2-methoxyethane (0.77 mL, 8.15 mmol) and sodium hydride (60%) (386 mg, 9.66 mmol) in tetrahydrofuran/N,N-dimethylformamide (2:1) (60 mL) was heated at 75° C. for 12 hours. The mixture was cooled to ambient temperature, diluted with water, and extracted with dichloromethane. The organic extract was dried (Na2SO4), filtered and concentrated. Purification by chromatography (silica gel, 100% dichloromethane) afforded the title compound. MS (ESI) m/z 399 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09006275B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-7c402f77464f41a7acfbf9fdd31b2503 |
| 출처 메모 | uspto-grants-2015_04 |