HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanamide → 5-(2,2,2-Trifluoroethyl)thiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 4,4,4-Trifluorobutanal | HCID 2777083 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Product | 5-(2,2,2-Trifluoroethyl)thiazol-2-amine | HCID 86619051 | — |
Reaction Steps
A mixture of 4,4,4-trifluorobutyraldehyde (Matrix), pyrrolidine, p-toluenesulfonic acid monohydrate, sulfur and cyanamide were processed using the method described in Example 136A to obtain the title compound. MS (ESI+) m/z 183 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006275B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-c04e4a98c38d4261afb298de5926c69a |
| Source note | uspto-grants-2015_04 |