HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1470027Generated: November 1, 2026
2-Bromoethyl methyl ether → Ammonium Hydroxide
https://huagongshe.com/reaction/1470027
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-(2-methoxyethyl)-5-methylthiazol-2(3H)-imine | HCID 66859952 | — |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (10 g, 88 mmol) and 2-bromoethylmethyl ether (9.1 mL, 96 mmol) was warmed to 85° C. and stirred for 4.5 hours. The mixture was cooled to ambient temperature and the residue was purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 173 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09006275B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-11e212df6b5d49aa85e36a3534ecdcc0 |
|---|
| Source note | uspto-grants-2015_04 |
|---|
