HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → (Tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | (Oxan-4-yl)methanol | HCID 2773573 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (Tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate | HCID 19077576 | — |
Reaction Steps
Tetrahydro-2-H-pyran-4-ylmethanol (Combi-Blocks, 2.0 g, 17 mmol) and p-toluenesulfonyl chloride (3.5 g, 18 mmol) in 10 mL of CH2Cl2 and 10 mL of pyridine were processed as in Example 160A to afford the title compound. MS (DCI/NH3) m/z 288 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006275B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-404e9d4b49d44f13bc78ddce2a230bc1 |
| Source note | uspto-grants-2015_04 |