2-Amino-5-methylthiazole → Ammonium Hydroxide

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-5-methylthiazole (0.87 g, 7.6 mmol) and 1-bromo-3-methoxypropane (Matrix, 1.3 g, 8.5 mmol) was warmed to 85° C. and stirred for 5 hours. The mixture was cooled to ambient temperature and the residue was purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to provide the title compound. MS (DCI/NH3) m/z 187 (M+H)+.

Provenance & Evidence