2-(Aminomethyl)-1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-pentanol → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-4-methyl-2-pentanol

HRID 147021Notes

Reaction equation

HRID 147021 reaction equation
[Br:22][c:23]1[c:24]2[cH:25][n:26][n:27](-[c:33]3[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]3)[c:28]2[cH:29][c:30]([CH3:32])[cH:31]1.[NH2:1][CH2:2][C:3]([C:4]([F:5])([F:6])[F:7])([CH2:8][C:9]([CH3:10])([CH3:11])[c:12]1[c:13]([O:19][CH3:20])[cH:14][cH:15][c:16]([F:18])[cH:17]1)[OH:21]>>[NH:1]([CH2:2][C:3]([C:4]([F:5])([F:6])[F:7])([CH2:8][C:9]([CH3:10])([CH3:11])[c:12]1[c:13]([O:19][CH3:20])[cH:14][cH:15][c:16]([F:18])[cH:17]1)[OH:21])[c:23]1[c:24]2[cH:25][n:26][n:27](-[c:33]3[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]3)[c:28]2[cH:29][c:30]([CH3:32])[cH:31]1

Participants

3

Reactant 2

HCID 179365862-(Aminomethyl)-1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-pentanolHCID 576159341h-Indazole,4-bromo-1-(4-fluorophenyl)-6-methyl-

Product 1

HCID 119924331,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-4-methyl-2-pentanol

Sources & evidence

ORD record
ord-67ae0852a496429493eb735016ddd502
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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