反应详情

4-[4-Amino-4-(4-tert-butyl-benzyl)-piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (23 mg, 0.053 mmol) was suspended in 2M potassium hydroxide (1 mL) and irradiated in a microwave reactor (250 W) for 2 hours at 120° C. After cooling, water (2 mL) was added and the aqueous layer was extracted with ethyl acetate (2×4 mL). The organic layers were dried (Na2SO4) and concentrated to give a yellow solid (9 mg, 47%). LC-MS (LCT2) m/z 364 [M+H+], Rt 2.80 min.

1. customirradiated in a microwave reactor (250 W) for 2 hours at 120° C
2. temperatureAfter cooling
3. extractionthe aqueous layer was extracted with ethyl acetate (2×4 mL)
4. dry with materialThe organic layers were dried (Na2SO4)
5. concentrationconcentrated