Pyridine-2-carbonitrile → Pyridine-2-carboximidamide hydrochloride

Participants

Reaction Steps

To a solution of 2-cyanopyridine (10-a) (Sigma-Aldrich) (100 g, 0.95 mol) in methanol (1.5 L) under nitrogen was added sodium methoxide (2.5 g, 44 mmol). The reaction mixture was stirred at room temperature for 24 hours. Ammonium chloride (53.5 g, 1 mol) was added to the reaction mixture. The mixture was stirred at room temperature for 4 h and the solvent was removed in vacuo. The residue was washed with ipropanol/ethyl acetate=1/10 and dried in vacuo to provide compound 10-b (100 g, 66%).

Provenance & Evidence