HCID 178418361, compound → HCID 178508021, compound

HRID 1470315Notes

Reaction equation

HRID 1470315 reaction equation
[OH:1][C:2]1[C:7]([NH:8]C(=O)OCC2C=CC=CC=2)=[CH:6][N:5]=[C:4]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[N:3]=1.[H][H]>CO.[Pd]>[NH2:8][C:7]1[C:2]([OH:1])=[N:3][C:4]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[N:5][CH:6]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178522378HCID 178522378, compound

Product 1

HCID 178508021HCID 178508021, compoundYield 41.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl 4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-ylcarbamate (10-d) (1 g, 3.1 mmol) in methanol (20 ml) was hydrogenated under 1 atm of hydrogen in the presence of Pd/C (500 mg) overnight. The mixture was filtered and the filtrate was concentrated to provide the crude product, 10-e (240 mg).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-e9154879baac4af1908199161d166cef
Source dataset
uspto-grants-2015_04
Patent number
US09006433B2

Reaction notes

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