HCID 66779914, compound → HCID 66779799, compound

Participants

Reaction Steps

7-(3-Benzyloxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-furo[3,2-b]pyridine (0.137 mmol) is dissolved in THF (10 ml) and Pd—C 5% (0.2 g) is added, and the compound is hydrogenated 2 days at room temperature. The reaction solution is filtered and the filtrate removed in vacuo. The precipitate is suspended in diethylether and filtrated. The product is obtained after drying at 40° C. for 4 h as yellow solid (23 mg, 44%); HPLC (method A): Rt 2.55 min (purity 99.2%); LCMS (ESI+) (method E): Rt 1.995 min, M+H+ 378.1 m/z; 1H NMR (400 MHz, DMSO-d6) δ [ppm] 9.73 (s, 1H), 8.54 (d, J=5.1, 1H), 7.72 (s, 1H), 7.60-7.55 (m, 1H), 7.55-7.48 (m, 2H), 7.42 (t, J=7.9, 1H), 7.32 (s, 2H), 6.96-6.91 (m, 1H), 3.91 (s, 6H), 3.74 (s, 3H).

Provenance & Evidence