2-Amino-2-methyl-1-propanol → HCID 66779785, compound

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Reaction Steps

Starting from 2,3-dimethoxy-5-(7-phenylfuro[3,2-b]pyridin-2-yl)benzoic acid (120 μmol) and 2-Amino-2-methylpropan-1-ol (123 μmol) the product is prepared analogously to “A43” and obtained as a yellow solid in a yield of 28%. HPLC (method A): Rt 2.64 min (purity 93.5%); LCMS (ESI+) (method E): Rt 1.9 min, M+H+ 447.2 m/z; 1H NMR (500 MHz, DMSO-d6) δ [ppm] 8.61 (d, J=5.2, 1H), 8.21 (s, 1H), 8.13-8.08 (m, 2H), 7.89 (d, J=2.1, 1H), 7.82 (s, 1H), 7.78 (d, J=2.1, 1H), 7.70-7.63 (m, 3H), 7.61-7.55 (m, 1H), 3.98 (s, 3H), 3.90 (s, br, 1H), 3.86 (s, 3H), 3.46 (s, 2H), 1.35 (s, 6H).

Provenance & Evidence