Water → HCID 68084481, compound

Participants

Reaction Steps

3-[2-(3,4,5-Trimethoxy-phenyl)-furo[3,2-b]pyridin-7-yl]-benzoic acid (0.049 mmol) is dissolved in N,N-dimethylformamid (1.00 ml) and N-(3-dimethyl-aminopropyl)-N′-ethylcarbodiimidhydrochloride (0.110 mmol), 1-hydroxybenzotriazolhydrat (0.111 mmol), 4-Methylmorpholin (0.146 mmol) and 1,2-Diaminocyclohexane (0.049 mmol) are added. The reaction solution is stirred 2 d at RT. Water is added and the solvent removed in vacuo. The product is isolated after column reversed phase column chromatography as yellow solid in a yield of 27%. HPLC (method A): Rt 2.47 min (purity 100%); LCMS (ESI+) (method E): Rt 1.69 min, M+H+ 502.2 m/z.

Provenance & Evidence