N,N-Dimethyl-1,3-propanediamine → HCID 66779476, compound

Participants

Reaction Steps

Starting from 3-[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]benzoic acid (0.062 mmol) and N,N-dimethyltrimethylendiamin (0.064 mmol) the product is prepared analogously to “A43” and obtained as yellow solid in a yield of 33%. HPLC (method A): Rt 2.45 min (purity 99.3%); LCMS (ESI+) (method E): Rt 1.56 min, M+H+ 490.3 m/z; 1H NMR (500 MHz, DMSO-d6) δ [ppm] 8.82 (s, 1H), 8.77-8.68 (m, 1H), 8.60 (d, J=5.1, 1H), 8.27 (d, J=7.8, 1H), 8.01 (d, J=7.8, 1H), 7.78 (s, 1H), 7.77-7.69 (m, 2H), 7.37 (s, 2H), 3.93 (s, 6H), 3.74 (s, 3H), 3.49-3.18 (m, 2H), 2.45-2.10 (m, 8H), 1.78-1.63 (m, 2H).

Provenance & Evidence