4-Methylmorpholine → HCID 56848568, compound

Participants

Reaction Steps

Starting from 3-[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]benzoic acid (0.062 mmol) and 4-methylmorpholin (0.182 mmol) the product is prepared analogously to “A43” and obtained as colorless solid in a yield of 70%. HPLC (method A): Rt 2.59 min (purity 98.1%); LCMS (ESI+) (method E): Rt 1.76 min, M+H+ 475.2 m/z; 1H NMR (500 MHz, DMSO-d6) δ [ppm] 8.58 (d, J=5.1, 1H), 8.29 (t, J=1.5, 1H), 8.19 (d, J=8.0, 1H), 7.76 (s, 1H), 7.74-7.65 (m, 2H), 7.58 (d, J=7.6, 1H), 7.33 (s, 2H), 3.91 (d, J=11.4, 6H), 3.74 (s, 3H), 3.69-3.37 (m, 8H).

Provenance & Evidence