HCID 56849421, compound → HCID 66779373, compound

Participants

Reaction Steps

3-[2-(3,4,5-Trimethoxy-phenyl)-furo[3,2-b]pyridin-7-yl]-benzonitrile (0.067 mmol) is dissolved in methanol/NH3 (10%, 10 ml) and sponge nickel catalyst (70%, 0.1 g) is added. The mixture is hydrogenated at 5.6 bar at 50° C. for 15 h. The suspension is filtrated and the solvent removed in vacuo. The precipitate is suspended in diethylether and filtrated. The product is obtained after drying in vacuo as slight green solid (67% yield). HPLC (method A): Rt 2.41 min (purity 97.3%); LCMS (ESI+) (method E): Rt 1.527 min, M+H+ 391.1 m/z; 1H NMR (400 MHz, DMSO-d6) δ [ppm] 8.56 (d, J=4.8, 1H), 8.25 (s, 1H), 7.93 (d, J=7.1, 1H), 7.74 (s, 1H), 7.65-7.45 (m, 3H), 7.34 (s, 2H), 3.92 (s, 6H), 3.88 (s, 2H), 3.81-3.68 (m, 5H).

Provenance & Evidence