HCID 56849420, compound → HCID 68083685, compound

Participants

Reaction Steps

7-(3-Nitro-phenyl)-2-(3,4,5-trimethoxy-phenyl)-furo[3,2-b]pyridine (0.121 mmol) is dissolved in THF (10 ml) and Pd—C 5% (0.2 g) is added and the reaction is hydrogenated 16 h at RT. The mixture is filtered and the filtrate removed in vacuo. The precipitate is suspended in diethylether and filtrated. The product is obtained after reversed phase column chromatography as yellow solid in a yield of 27%. HPLC (method A): Rt 2.45 min (purity 99.2%); LCMS (ESI+) (method E): Rt 1.89 min, M+H+ 377.1 m/z; 1H NMR (400 MHz, DMSO-d6) δ [ppm] 8.60 (d, J=5.3, 1H), 7.80 (s, 1H), 7.71-7.55 (m, 2H), 7.51-7.33 (m, 4H), 6.97 (d, J=6.9, 1H), 4.42 (s, br, 2H), 3.93 (s, 6H), 3.75 (s, 3H).

Provenance & Evidence