3-(Methylsulfonyl)benzylamine hydrochloride → (3-Methanesulfonyl-benzyl)-(2-phenyl-furo[3,2-b]pyridin-7-yl)-amine

Participants

Reaction Steps

The title compound was prepared by procedure D using 7-chloro-2-phenyl-furo[3,2-b]pyridine (50.00 mg; 0.22 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and using 3-(methylsulfonyl)-benzylamine hydrochloride (57.92 mg; 0.26 mmol; 1.20 eq.) instead of N-(3-aminomethyl-pyridin-2-yl)-N-methyl-methanesulfonamide and was obtained as a waxy yellow solid (73 mg, 88%). (HPLC (method F): 98%, RT: 3.37 min); MS (m/z) 379 [M+H]+, RT: 2.2 min.

Provenance & Evidence