4-Methyl-1H-indol-5-amine → HCID 66779756, compound

HRID 1470362Notes

Reaction equation

HRID 1470362 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:10][C:3]=12.[CH3:17][C:18]1[C:26]([NH2:27])=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2>>[CH3:17][C:18]1[C:26]([NH:27][C:2]2[CH:7]=[CH:6][N:5]=[C:4]3[CH:8]=[C:9]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)[O:10][C:3]=23)=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2

Participants

3

Reactant 2

HCID 154344964-Methyl-1H-indol-5-amineHCID 667792417-Chloro-2-phenyl-furo[3,2-b]pyridine

Product 1

HCID 66779756HCID 66779756, compound

Procedure

The title compound was prepared by procedure E using 7-chloro-2-phenylfuro[3,2-b]pyridine (60.00 mg; 0.26 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (40.10 mg; 0.27 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one and was obtained as a brown oil (88 mg, 98%). (HPLC (method F): 96%, RT: 3.91 min); MS (m/z) 340 [M+H]+, RT: 2.7 min.

Sources & evidence

ORD record
ord-1ca0fcdfb00e4821af125c6fbadb57d7
Source dataset
uspto-grants-2015_04
Patent number
US09006440B2

Reaction notes

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