4-methyl-1H-indol-5-amine → HCID 66779741, compound

Participants

Reaction Steps

The title compound was prepared by procedure E using 7-chloro-2-(3,5-dimethylphenyl)furo[3,2-b]pyridine (26.00 mg; 0.10 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (15.49 mg; 0.11 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one, and was obtained as a beige solid (25 mg, 67%). (HPLC (method F): 96%, RT: 4.45 min); 1H NMR (500 MHz, DMSO-d6) δ [ppm] 11.15 (s, 1H), 8.54 (s, 1H), 7.95 (d, J=5.5, 1H), 7.50 (s, 2H), 7.38 (t, J=2.7, 1H), 7.33 (s, 1H), 7.31 (d, J=8.4, 1H), 7.08-6.95 (m, 2H), 6.52 (s, 1H), 6.14 (d, J=5.5, 1H), 2.36 (s, 3H), 2.30 (s, 6H); MS (m/z) 368 [M+H]+, RT: 4.3 min.

Provenance & Evidence