4-methyl-1H-indol-5-amine → HCID 68083905, compound

Participants

Reaction Steps

The title compound was prepared by procedure E using 7-chloro-2-(3-methoxyphenyl)furo[3,2-b]pyridine (29.70 mg; 0.11 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (17.56 mg; 0.12 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one, and was obtained as a beige solid (25 mg, 59%). (HPLC (method F): 98%, RT: 3.96 min); 1H NMR (500 MHz, DMSO-d6) δ[ppm] 11.15 (s, 1H), 8.58 (s, 1H), 7.96 (d, J=5.4, 1H), 7.55 (d, J=7.6, 1H), 7.49 (s, 1H), 7.47 (s, 1H), 7.42-7.35 (m, 2H), 7.31 (d, J=8.4, 1H), 7.01 (d, J=8.5, 1H), 6.98 (d, J=8.0, 1H), 6.52 (s, 1H), 6.12 (d, J=5.4, 1H), 3.79 (s, 3H), 2.36 (s, 3H); MS (m/z) 370 [M+H]+, RT: 3.8 min.

Provenance & Evidence