4-methyl-1H-indol-5-amine → HCID 66779317, compound

Participants

Reaction Steps

The title compound was prepared by procedure E using 7-chloro-2-(2,3-dimethoxyphenyl)furo[3,2-b]pyridine (30.00 mg; 0.10 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (15.89 mg; 0.11 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one, and was obtained as a beige solid (15 mg, 37%). (HPLC (method F): 99%, RT: 4.00 min); 1H NMR (500 MHz, DMSO-d6) δ [ppm] 11.16 (s, 1H), 8.59 (s, 1H), 7.97 (d, J=5.5, 1H), 7.60 (d, J=7.6, 1H), 7.43-7.36 (m, 1H), 7.36-7.27 (m, 2H), 7.20-7.11 (m, 2H), 7.00 (d, J=8.5, 1H), 6.52 (s, 1H), 6.10 (d, J=5.5, 1H), 3.88 (s, 3H), 3.87 (s, 3H), 2.36 (s, 3H); MS (m/z) 400 [M+H]+, RT: 3.3 min.

Provenance & Evidence