4-methyl-1H-indol-5-amine → HCID 66778958, compound

Participants

Reaction Steps

The title compound was prepared by procedure E using [4-(7-chlorofuro[3,2-b]pyridin-2-yl)phenyl]methanol (20.40 mg; 0.08 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (12.06 mg; 0.08 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one, and was obtained as a beige solid (8 mg, 28%). (HPLC (method F): 97%, RT: 3.30 min); 1H NMR (500 MHz, DMSO-d6) δ [ppm] 11.14 (s, 1H), 8.54 (s, 1H), 7.94 (d, J=5.4, 1H), 7.91 (d, J=8.2, 2H), 7.42 (d, J=8.1, 2H), 7.40-7.35 (m, 2H), 7.30 (d, J=8.3, 1H), 7.00 (d, J=8.4, 1H), 6.52 (s, 1H), 6.09 (d, J=5.4, 1H), 5.26 (s, 1H), 4.55 (d, J=5.6, 2H), 2.36 (s, 3H); MS (m/z) 370 [M+H]+, RT: 3.2 min.

Provenance & Evidence