4-methyl-1H-indol-5-amine → HCID 56848875, compound

Participants

Reaction Steps

The title compound was prepared by procedure E using 2-[4-(7-chlorofuro[3,2-b]pyridin-2-yl)phenyl]propan-2-ol (29.50 mg; 0.10 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (15.74 mg; 0.11 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one, and was obtained as a beige solid (26 mg, 66%). (HPLC (method F): 93%, RT: 4.44 min); 1H NMR (500 MHz, DMSO-d6) δ[ppm] 11.14 (s, 1H), 8.57 (s, 1H), 7.99-7.90 (m, 3H), 7.62 (d, J=8.5, 2H), 7.44 (s, 1H), 7.38 (t, J=2.7, 1H), 7.31 (d, J=8.4, 1H), 7.01 (d, J=8.4, 1H), 6.52 (s, 1H), 6.09 (d, J=5.5, 1H), 5.55 (s, 1H), 5.18 (s, 1H), 2.36 (s, 3H), 2.16 (s, 3H); MS (m/z) 380 [M+H]+, RT: 4.4 min.

Provenance & Evidence