4-methyl-1H-indol-5-amine → HCID 66779727, compound

Participants

Reaction Steps

The title compound was prepared by procedure E using 7-chloro-2-(3,5-dimethylisoxazol-4-yl)furo[3,2-b]pyridine (25.10 mg; 0.10 mmol; 1.00 eq.) instead of 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine, and 4-methyl-1H-indol-5-ylamine (15.49 mg; 0.11 mmol; 1.05 eq.) instead of 6-amino-2,2-difluoro-4H-benzo[1,4]oxazin-3-one, and was obtained as a beige solid (19 mg, 52%). (HPLC (method F): 99%, RT: 3.49 min); 1H NMR (500 MHz, DMSO-d6) δ [ppm] 11.13 (s, 1H), 8.49 (s, 1H), 7.98 (d, J=5.5, 1H), 7.37 (t, J=2.7, 1H), 7.29 (d, J=8.5, 1H), 7.07 (s, 1H), 6.99 (d, J=8.4, 1H), 6.51 (s, 1H), 6.17 (d, J=5.5, 1H), 2.52 (s, 3H), 2.37 (s, 3H), 2.34 (s, 3H); MS (m/z) 359 [M+H]+, RT: 3.4 min.

Provenance & Evidence