{3-[(4-Fluorophenyl)carbamoyl]phenyl}boronic acid → HCID 56848876, compound

Participants

Reaction Steps

The title compound was prepared by procedure C using 7-chloro-2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine (45.00 mg; 0.14 mmol; 1.00 eq.) instead of 7-chloro-2-iodo-furo[3,2-b]pyridine, and 3-(4-fluorophenyl)aminocarbonyl-phenylboronic acid (40.10 mg; 0.15 mmol; 1.10 eq.) instead of 4-fluorophenylboronic acid and was obtained as a white solid (57 mg, 81%). (HPLC (method F): 87%, RT: 4.33 min); 1H NMR (500 MHz, DMSO-d6) δ [ppm] 10.51 (s, 1H), 8.96 (s, 1H), 8.67-8.58 (m, 1H), 8.34 (d, J=7.4, 1H), 8.15 (d, J=7.4, 1H), 7.88-7.74 (m, 5H), 7.38 (s, 2H), 7.24 (t, J=7.8, 2H), 3.87 (s, 6H), 3.77-3.68 (m, 3H); MS (m/z) 499 [M+H]+, RT: 4.3 min.

Provenance & Evidence