Water → HCID 56848930, compound

Participants

Reaction Steps

To a 10-mL microwave vial was added 3-(7-chlorofuro[3,2-b]pyridin-2-yl)aniline (88.20 mg; 0.36 mmol), 4-phenoxyphenol (100.68 mg; 0.54 mmol), and cesium carbonate (352.35 mg, 1.08 mmol). The reagents were suspended in DMF (5.00 ml) and run in the microwave reactor at 160° C. for 2 hours. The reaction mixture was cooled to room temperature. Water and brine were added to the reaction mixture which was then extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated. The crude mixture was purified using Biotage column chromatography (20-100% EtOAc/Hexanes) to afford the title compound as a white solid (111.70 mg, 79%). HPLC (method F): 91%, RT=3.949 min. MS: m/z=395 [M+H]+, RT=3.80 min.

Provenance & Evidence