HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Hydroxy-5-methylisoquinolin-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Methoxy-5-methylisoquinolin-4-carboxylic acid | HCID 68281882 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 1-Hydroxy-5-methylisoquinolin-4-carboxylic acid | HCID 178423911 | 53.7% |
Reaction Steps
A solution of 1-methoxy-5-methylisoquinolin-4-carboxylic acid (Intermediate-8) (1.2 g, 5.5 mmol) in HBr (48% aq. solution, 20 mL) was stirred at RT for 24 h. After completion (TLC), the reaction mixture was poured into water, filtered, washed with water (4×25 mL), and then dried to afford title compound (600 mg, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006442B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-6a11a2fa24c84439a0ab8d7cde92f19e |
| Source note | uspto-grants-2015_04 |