6-Oxa-3-azabicyclo[3.1.1]heptane → HCID 86689581, compound

HRID 1470465Notes

Reaction equation

HRID 1470465 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[CH:16]12[CH2:22][CH:20]([O:21]1)[CH2:19][NH:18][CH2:17]2>>[CH:20]12[CH2:22][CH:16]([O:21]1)[CH2:17][N:18]([C:13]([C:5]1[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][C:7]=3[CH3:12])[C:2]([Cl:1])=[N:3][CH:4]=1)=[O:15])[CH2:19]2

Participants

3

Reactant 2

HCID 179658576-Oxa-3-azabicyclo[3.1.1]heptaneHCID 84687221HCID 84687221, compound

Product 1

HCID 86689581HCID 86689581, compound

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 6-oxa-3-azabicyclo[3.1.1]heptane by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record
ord-a23981a7480541b69b6a17b9295b2990
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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