2-Oxa-5-azabicyclo(2.2.1)heptane → HCID 86689585, compound

HRID 1470469Notes

Reaction equation

HRID 1470469 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[CH:16]12[CH2:22][CH:19]([NH:20][CH2:21]1)[CH2:18][O:17]2>>[CH:16]12[CH2:22][CH:19]([NH:20][CH2:21]1)[CH:18]([C:13]([C:5]1[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][C:7]=3[CH3:12])[C:2]([Cl:1])=[N:3][CH:4]=1)=[O:15])[O:17]2

Participants

3

Reactant 2

HCID 36145512-Oxa-5-azabicyclo(2.2.1)heptaneHCID 84687221HCID 84687221, compound

Product 1

HCID 86689585HCID 86689585, compound

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 2-oxa-5-azabicyclo[2.2.1]heptane by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record
ord-5d12ed8cceb8416da28ceb3a8a021729
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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