2-Phenylmorpholine → HCID 86689587, compound

HRID 1470471Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[C:16]1([CH:22]2[O:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:24]2[CH2:25][CH2:26][O:27][CH:22]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:23]2)=[O:15])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 911012-Phenylmorpholine

HCID 84687221HCID 84687221, compound

Product 1

HCID 86689587HCID 86689587, compound

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 2-phenylmorpholine by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record: ord-c4561fbd10cc4d12a3dbc2b93426f80b
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006442B2

Reaction notes

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