Cyclohexylamine → 1-Chloro-N-cyclohexyl-5-methylisoquinolin-4-carboxamide

HRID 1470472Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([NH:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 7965Cyclohexylamine

HCID 84687221HCID 84687221, compound

Product 1

HCID 866895881-Chloro-N-cyclohexyl-5-methylisoquinolin-4-carboxamide

Procedure

This compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and cyclohexylamine by following the similar procedure as described for intermediate-11a.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-d0ce764f74ad4bafb2387ca3ccb2446e
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006442B2

Reaction notes

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