Azetidine → HCID 86689590, compound

HRID 1470474Notes

Reaction equation

HRID 1470474 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[NH:16]1[CH2:19][CH2:18][CH2:17]1>>[N:16]1([C:13]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][C:7]=3[CH3:12])[C:2]([Cl:1])=[N:3][CH:4]=2)=[O:15])[CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 84687221HCID 84687221, compound

Product 1

HCID 86689590HCID 86689590, compound

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and azetidine by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record
ord-af28af46f0b54a87875ae98cd8ed2735
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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