4,4-Difluoropiperidine → HCID 86689593, compound

HRID 1470477Notes

Reaction equation

HRID 1470477 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[F:16][C:17]1([F:23])[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:20]2[CH2:21][CH2:22][C:17]([F:23])([F:16])[CH2:18][CH2:19]2)=[O:15])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 27583524,4-DifluoropiperidineHCID 84687221HCID 84687221, compound

Product 1

HCID 86689593HCID 86689593, compound

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 4,4-difluoropiperidine by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record
ord-7068c3ef5c6040c08377c1e40938cd71
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

Loading…