反应详情

To a stirred solution of isoquinolin-4-carbonitrile (Intermediate-13) (3.0 g, 19.45 mmol) in EtOH (30 mL) was added KOH (20 g in 20 mL water) and the mixture was refluxed overnight. It was then cooled to RT and concentrated under reduced pressure. The aqueous layer was washed with Et2O and neutralized using 1N HCl. It was extracted with EtOAc and the organic layer was dried over Na2SO4, filtered, and concentrated to give the title compound (2 g, 59.3%) as an off white solid.

1. temperaturethe mixture was refluxed overnight
2. concentrationconcentrated under reduced pressure
3. washThe aqueous layer was washed with Et2O
4. extractionIt was extracted with EtOAc
5. dry with materialthe organic layer was dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated