Trifluoromethanesulfonic anhydride → HCID 88921461, compound

Participants

Reaction Steps

To a solution of (4-hydroxy-8-methylnaphthalen-1-yl)(morpholino)methanone (above Step-7 intermediate) (1 equiv) in dry CH2Cl2 (4 mL) under nitrogen was added DIPEA (3 equiv) at 0° C. and the mixture was stirred for 10 min. To this, Tf2O (1.5 equiv) was added drop wise and the reaction mixture was stirred for another 1.5 h at 0° C. Then it was slowly quenched with water (10 mL) and the aqueous layer was extracted with CH2Cl2 (4×10 mL). The combined organic layer was washed with water (10 mL), brine (10 mL), dried (Na2SO4) and filtered. The solvent was removed under reduced pressure and the residue was purified by column to give the title compound.

Provenance & Evidence