2-Oxa-5-azabicyclo(2.2.1)heptane → 2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl(4-methoxy-8-methylnaphthalen-1-yl)methanone

HRID 1470496Notes

Reaction equation

HRID 1470496 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[C:6]([C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH:17]12[CH2:23][CH:20]([NH:21][CH2:22]1)[CH2:19][O:18]2>>[CH:17]12[CH2:23][CH:20]([N:21]([C:14]([C:6]3[C:7]4[C:12](=[CH:11][CH:10]=[CH:9][C:8]=4[CH3:13])[C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[O:16])[CH2:22]1)[CH2:19][O:18]2

Participants

3

Reactant 2

HCID 36145512-Oxa-5-azabicyclo(2.2.1)heptaneHCID 68282059HCID 68282059, compound

Product 1

HCID 682818732-Oxa-5-azabicyclo[2.2.1]heptan-5-yl(4-methoxy-8-methylnaphthalen-1-yl)methanone

Procedure

4-Methoxy-8-methyl-1-naphthoic acid (Step-5 of Intermediate-22) was reacted with 2-oxa-5-azabicyclo[2.2.1]heptane by following the similar procedure as described in Step-6 of Intermediate-22.

Sources & evidence

ORD record
ord-38e128a21e544ea686007829ddcc2008
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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