3-Azabicyclo(3.1.0)hexane → 3-Azabicyclo[3.1.0]hexan-3-yl(4-methoxy-8-methylnaphthalen-1-yl)methanone

HRID 1470497Notes

Reaction equation

HRID 1470497 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[C:6]([C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH:17]12[CH2:22][CH:21]1[CH2:20][NH:19][CH2:18]2>>[CH:17]12[CH2:22][CH:21]1[CH2:20][N:19]([C:14]([C:6]1[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][C:8]=3[CH3:13])[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:16])[CH2:18]2

Participants

3

Reactant 2

HCID 131505233-Azabicyclo(3.1.0)hexaneHCID 68282059HCID 68282059, compound

Product 1

HCID 682820283-Azabicyclo[3.1.0]hexan-3-yl(4-methoxy-8-methylnaphthalen-1-yl)methanone

Procedure

4-Methoxy-8-methyl-1-naphthoic acid (Step-5 of Intermediate-22) was reacted with 3-azabicyclo[3.1.0]hexane by following the similar procedure as described in Step-6 of Intermediate-22.

Sources & evidence

ORD record
ord-55b793978e5c4ce9a225c7f5dbcdc3a4
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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