2-Oxa-6-azaspiro[3.3]heptane → (4-Methoxy-8-methylnaphthalen-1-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone

HRID 1470500Notes

Reaction equation

HRID 1470500 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[C:6]([C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH2:17]1[C:20]2([CH2:23][NH:22][CH2:21]2)[CH2:19][O:18]1>>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[C:6]([C:14]([N:22]2[CH2:23][C:20]3([CH2:17][O:18][CH2:19]3)[CH2:21]2)=[O:16])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 231118872-Oxa-6-azaspiro[3.3]heptaneHCID 68282059HCID 68282059, compound

Product 1

HCID 68281826(4-Methoxy-8-methylnaphthalen-1-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone

Procedure

4-Methoxy-8-methyl-1-naphthoic acid (Step-5 of Intermediate-22) was reacted with 2-oxa-6-azaspiro[3.3]heptane by following the similar procedure as described in Step-6 of Intermediate-22.

Sources & evidence

ORD record
ord-15c4a35f6b5d41a3be0e76800f1269bc
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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