Diisopropylethylamine → HCID 68281996, compound

Participants

Reaction Steps

To a solution of 1-methoxy-5-methylisoquinolin-4-sulfonylchloride (Intermediate-38) (1 equiv) in CH2Cl2 was added, DIPEA (2 equiv) and the corresponding amine (1.3 equiv) under N2 and the mixture was stirred for 10 min at 0° C. and then at RT for 1 h. It was quenched with ice water, extracted with CH2Cl2 (2×100 mL), washed with water (1×100 mL), dried, filtered and concentrated under reduced pressure to furnish the product in 69-75% yield.

Provenance & Evidence