Hydrochloric Acid → HCID 123736608, compound

Participants

Reaction Steps

To a solution of 3,4,5-trimethoxyacetophenone (194 mg, 0.925 mmol) in methanol (5 mL) was added 2N Ba(OH)2 solution (2 ml) and stirred for 5 minutes followed by the addition of 2-(4-fluorophenylamino)nicotinaldehyde (200 mg, 0.925 mmol) and the reaction mixture was stirred at a temperature of 30° C. for 6h and the reaction was monitored by TLC. After 8h the reaction mixture is acidified with 2N HCl. The resulting precipitate was filtered, washed thoroughly with water and dried over anhydrous CaCl2. The precipitate was recrystallized using ethanol to obtain pure (6aj) (340 mg, 90% yield).

Provenance & Evidence