Hydrochloric Acid → HCID 123437096, compound

Participants

Reaction Steps

To a solution of 3,4,5-trimethoxyacetophenone (135 mg, 0.06465 mmol) in methanol (5 mL) was added 2N Ba(OH)2 solution (2 mL) and stirred for 5 minutes. Then added 2-(4-chlorophenylamino)nicotinaldehyde (150 mg, 0.0.6465 mmol) and the reaction mixture was stirred at a temperature of 30° C. for 6h and the reaction was monitored by TLC. After 8h the reaction mixture is acidified with 2N HCl. The resulting precipitate was filtered, washed thoroughly with water and dried over anhydrous CaCl2. The precipitate was recrystallized using ethanol to obtain pure (6ax) (232 mg, 85% yield).

Provenance & Evidence