Pyridine →

Participants

Reaction Steps

A solution of thietan-3-ol (450 mg) and Et3N (1.3 ml) in chloroform (5 ml) was added dropwise to over 30 minutes to a solution of p-toluenesulfonic anhydride (1.63 g) in dichloromethane (10 ml) at −20° C. under argon atmosphere. After 2 hours, pyridine (0.8 ml) was added and the resulting mixture was stirred at room temperature for 2 days. The precipitated solid was collected by filtration (300 mg). 1H-NMR (DMSO, 400 MHz): 2.30 (s, 3H), 3.57 (t, 2H), 4.09 (t, 2H), 6.16 (q, 1H), 7.12 (d, 2H), 7.50 (d, 2H), 8.20 (t, 2H), 8.66 (t, 1H), 9.21 (d, 1H).

Provenance & Evidence