Sulfuric Acid → 7-nitroisatin

HRID 1470575Notes

Reaction equation

HRID 1470575 reaction equation
ON=[CH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14])=[O:5].S(=O)(=O)(O)[OH:17]>>[N+:13]([C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[NH:6][C:4](=[O:5])[C:3]2=[O:17])([O-:15])=[O:14]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 6785498HCID 6785498, compound

Product 1

HCID 38583087-nitroisatin

Procedure

2-Hydroxyimino-N-(2-nitro-phenyl)-acetamide (15 g, 72 mmol) was carefully added in small portions to a stirred solution of preheated (90° C.) conc. sulphuric acid (45 mL) over a period of 30 min and the resulting mixture was stirred for another 2 h at the same temperature. It was then cooled to room temperature, poured into crushed ice, the precipitated products was collected by filtrations. The collected precipitated products were washed with water and dried in a vacuum oven to get a brick red colour powder.

Workup

  1. customof 30 min
  2. additionpoured
  3. custominto crushed ice
  4. filtrationthe precipitated products was collected by filtrations
  5. customThe collected precipitated products
  6. washwere washed with water
  7. customdried in a vacuum oven
  8. customto get a brick red colour powder

Sources & evidence

ORD record
ord-3fd57298327d4cbea43d24359a686519
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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