HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 66706295, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,3-Diaminobenzoic acid methyl ester | HCID 571825 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 19933666 | HCID 19933666 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66706295 | HCID 66706295 | — |
Reaction Steps
To a stirred solution of 2,3-diamino-benzoic acid methyl ester (200 mg, 1.2 mmol, and biphenyl benzoic acid (238 mg, 1.2 mmol), HATU (1.14 g, 3 mmol) in dry DMF (5 mL) was added diisopropylethyl amine (0.6 mL, 3.6 mmol). The mixture was stirred at ambient temperature overnight and poured into water (50 mL). The precipitated solid was filtered and dried in a vacuum oven to afford the required compound which was used directly for the next step without any purification (300 mg, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006454B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-b1c3ab8a85ac4ce8a1451287aa3b6b27 |
| Source note | uspto-grants-2015_04 |