Nitric Acid → HCID 10330598, compound

HRID 1470603Notes

Reaction equation

HRID 1470603 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[C:9]2=[O:16]>OS(O)(=O)=O>[CH3:5][C:6]1[CH:7]=[C:8]2[C:12](=[C:13]([N+:1]([O-:4])=[O:2])[CH:14]=1)[NH:11][C:10](=[O:15])[C:9]2=[O:16]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 118405-Methylisatin

Product 1

HCID 10330598HCID 10330598, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Fuming nitric acid (10 mL) was added drop wise over a period of 30 min to a solution of 5-methyl-1H-indole-2,3-dione (20 g, 0.124 mol) in conc. H2SO4 (80 mL) at −5° C., utes. The reaction mass was stirred for another 5-10 min at the same temperature and was poured into crushed ice. The precipitate was filtered and washed with chilled water several times. Finally it was dried in a vacuum oven to get 6.5 g of the required product as a yellow coloured solid.

Workup

  1. additionwas poured
  2. custominto crushed ice
  3. filtrationThe precipitate was filtered
  4. washwashed with chilled water several times
  5. customFinally it was dried in a vacuum oven

Sources & evidence

ORD record
ord-f400fff904be4a7c87525164873259d0
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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