Methyl 2-amino-5-methyl-3-nitrobenzoate → Methyl 2,3-diamino-5-methylbenzoate

Participants

Reaction Steps

A solution of 2-amino-5-methyl-3-nitro-benzoic acid methyl ester (5.5 g, 26 mmol) in methanol (200 mL) was hydrogenated with hydrogen balloon in presence of 10% Palladium on charcoal (1.5 g) for 12 h. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to get the required product as a brown coloured solid 4.5 g (95%).

Provenance & Evidence