Acetone → 3'-(Trifluoromethoxy)[1,1'-biphenyl]-4-carboxylic acid

Participants

Reaction Steps

To a cold solution of 3′-trifluoromethoxy-biphenyl-4-carbaldehyde (0.8 g, 3.0 mmol) in acetone (10 mL) the Jone's reagent was added slowly at 0° C. until reaction completes. Acetone was removed completely and diluted with water. The mixture was extracted with ethyl acetate and the combined organic layers were washed with water and brine, dried over sodium sulphate and concentrated to obtain the title compound (0.7 g, 82%).

Provenance & Evidence