Sodium Hydroxide → HCID 59828583, compound

Participants

Reaction Conditions

Reaction Steps

3-[(biphenyl-4-carbonyl)-amino]-2-hydroxy-benzoic acid methyl ester (100 mg, 0.28 mmol) was suspended in PPA (500 mg) and heated at 170° C. for 4 h. The reaction was monitored by TLC. After completion of the reaction, the crude mixture was cooled to room temperature and ice water was added. The pH was adjusted to 5 with an aq. solution of 5N NaOH and was extracted with ethyl acetate (3×50 mL). The combined organic phases were dried over sodium sulphate and concentrated under reduced pressure. The crude mixture was purified by column chromatography to get 35 mg of the required product as a pale pink coloured solid.

Provenance & Evidence